Five Hundred and Ninety-Eighth, I Finally Saw the Results

Medical Road Smooth Road Volume 598 Finally saw the results when Zhang Fan and his party were on the plane.

The Lancet published a heavyweight intestinal tumor paper.

And it was published by the tea hospital. Previously published papers are important, but they are not big inventions.

If it is not a small new discovery, it is an innovation in surgical technology.

This kind of paper is the accumulation of accumulation, which is helpful to the doctor's job title, and it cannot be improved to attract the attention of people other than non-hepatobiliary disciplines.

But the intestinal tumor paper published this time is different.

Wanziguo has cooperated with Chasu for almost a year.

From the beginning of the cooperation, Wanziguo first called for sick patients from their own country. During the first wave, Chasu people were shocked because they found that suddenly there were many bowing people on the street.

Colon cancer is the third most common cancer in the world, and there are many in the country of meatballs. I don't know if it is a genetic problem, or a problem of eating too much sashimi. Even the capital of their country has this problem.

It is said that there is a joke that one year, the Prime Minister of Maruko Kingdom reported to their emperor, but the two-hour report ended with seven or eight trips to the bathroom.

The emperor was also curious, thinking that the prime minister had taken a fancy to their toilet.

Therefore, when Wanziguo saw Zhang Fan's operation level on the intestinal tract, he began to vigorously cooperate with Chasu Hospital.

Originally, I wanted to lure Zhang Fan to the Maruko Kingdom, but the generation born in the 1980s grew up playing the land mine warfare soldier Zhang Ga repeatedly during the holidays. It is definitely not the same as the chess player. .

It is impossible to go to the country of meatballs.

Therefore, Wanzi Country can only cooperate with Chasu Hospital.

But in medical research, what is expensive is not what is in the laboratory.

It's the funding for clinical trials.

For example, a new drug needs to be developed.

When this thing was developed, the goal was to target the cardiovascular system.

First, live animal experiments, and dissection experiments.

But animals can't communicate with people when they play, they can only observe the target organs.

As a result, when it reaches the human body, the function of the cardiovascular system is too general.

But the doctors were surprised to find that this thing is effective for the third leg.

To be honest, if it didn't work for the third leg, Weiwei probably died in the first round of clinical trials that year.

None of these pre-tests and R&D are the most expensive.

Often the most expensive is getting into clinical trials. Many new drugs die in this area.

This kind of experiment first requires a large number of specimens, which are human beings, so many pharmaceutical companies go to Sange to do clinical trials.

It's not that the third brother's clinical trials are awesome, but that his medicine is cheap.

Hundreds of millions or even billions of research and development expenses are actually spent on several rounds of clinical trials.

Therefore, it is too expensive to bring patients from the country of meatballs. Then the patients from Outer Mongolia were encouraged to come.

For a while, after the bow was over, another group of men dressed similarly but differently appeared on Chasu Street.

The elderly local people saw it, yo, isn’t this the offspring who grazed us hundreds of years ago?

To be honest, anyway, the Mongols in China say that they are the golden ones, and the group outside used to graze them.

After a lot of investment, I finally saw the results.

Colon cancer is easy to develop, easy to transfer, and the mortality rate is extremely high.

And this time, the team of Chasu and Wanziguo finally discovered a factor that makes colon cancer metastasize.

The scariest thing about cancer is not how fast this thing grows. According to the current level of surgery, how fast you grow,

As long as it is not an important organ, it can actually be cut or embolized.

But the scary thing about this thing is that it has long legs, it can run and be contagious.

It is especially scary when it spreads. The first way is lymphatic metastasis. Lymphatic is originally the immune system. Once it is destroyed by cancer, the body will be exaggerated directly.

Therefore, when the doctor touches, taps and listens, he touches the lymph, especially when the doctor touches your steamed bun. This is not playing hooligans, but to see if your lymph nodes are swollen.

Of course, there are bad guys too.

In addition, it spreads from blood vessels. Where there is flesh, there are blood vessels. Once it enters the blood vessels, the chance of surgery is gone. It can only be detoxified by radiation and drugs. Often the result is that the cancer does not kill, and drugs and radiation Hang people up first.

The third type is direct invasion, such as rectal cancer, why surgery is terrible, because rectal cancer directly invades nearby organs.

For example, the male prostate, urethra, female genitalia and uterus, the common levator ani muscle, as well as the surrounding skin and bladder.

Therefore, the radical operation for rectal cancer is quite scary, and it is directly equivalent to digging out all the organs near the chrysanthemum.

In this kind of surgery, the chrysanthemum looks like a sunflower the size of a washbasin, and then all these organs are dug out, and what you see directly is the intestines.

The last one is planting like dandelions. After the cancer cells mature, this thing can swim in the body like a dandelion seed, and settle down wherever it lands.

But what is the reason for the cancer factor to escape and transfer.

The trouble is, the causes of metastasis vary among different cancers.

This time, the team of Tea Su and Wanziguo discovered the cause of colon cancer metastasis.

Creatine!

Creatine is not just an enzyme that catalyzes energy conversion in mammals. It is also an energy buffer.

To put it simply, for example, you were discovered by your wife for stealing food, and then you started to lie, your brain was running at a high speed, and as a result, there was not enough ATP, and ATP is equal to the gasoline of the human body.

This thing is not easy to store when it is produced, so it is often stored in the form of fat. When it is stored, everyone says it is good, but once it is used, this thing has to be decomposed, so when the energy is not enough.

When the brain is about to shut down, creatine takes its place.

For example, many iron lovers, in order to make the muscles bigger, or to make the turtle shell appear on the stomach.

Just supplement with creatine.

The Chasu Hospital found that creatine is good for normal people.

Can be found in colon cancer patients, creatine this thing also has a bad side.

This thing can promote cancer metastasis by activating the single-stage spindle to cause Smad2/3 signaling pathway.

In other words, cancer cells were originally eating leek boxes in the colon, but as a result, creatine is cheap, or there is too much energy, it shows its ability to open a gap between the intestinal tract and other organs, allowing colon cancer to escape. highway.

It's that simple.

What the disease is afraid of is not knowing the mechanism, not knowing what this thing is all about.

Just like SARS back then, why was it so scary, because it was impossible to research what it was.

But once found, there is always a way.

Although colon cancer has not discovered why it appears, it has discovered how it runs.

Although this cannot completely eliminate colon cancer, this discovery is already quite powerful.

If you can cut off the way it escapes, then even if it develops colon cancer, it is still a lamb waiting to be slaughtered. If it is a little disobedient, the doctor can cut off the intestines with lesions.

Therefore, this discovery is quite awesome. It can be said that this discovery, once a creatine drug corresponding to the inhibition of colon cancer is developed, will directly limit colon cancer to the colon.

After the team of Chasu and Wanzi succeeded in the experiment, conflicts broke out between the two sides.

This is the so-called common trouble can not be the same as the rich.

The meaning of Maruko Country is that they are the main force of the experiment.

They even paid for the test tube.

On Cha Su's side, Ren Li and the others will certainly not let go.

After arguing all morning, the two sides finally compromised.

Because there are many research teams all over the world on this thing, the paper must be published early after success, otherwise the paper spy will give it to other teams, and there will be no time to cry.

Then, the first author is a professor from Wanziguo, but the strange thing is that the corresponding author is Zhang Fan, and that's right, Zhang Fan.

Because there is not a top colonic expert and scholar here. But it was impossible to let go, so Zhang Fan was asked to stand up.

Moreover, because Zhang Fan directly relied on Zhang Fan for the previous operation, although Zhang Fan did not play a big role in the experiment, without Zhang Fan's precise separation of cancer in the early stage, they could not do the research.

Therefore, Zhang Fan became the corresponding author.

In fact, for papers, the first author is often very important, but the corresponding author is not bad.

The first author is often the main force of the experiment, the experimenter from beginning to end.

As for the corresponding author, he often came up with an idea, maybe he participated in the experiment or he didn't participate in the experiment. Therefore, the corresponding author is often the teacher or mentor of the first author.

However, he must be responsible for the experimental results and papers. It’s okay to win an award. For example, if there is a problem with the paper, the journal will not contact the first author, but the corresponding author.

The remaining one with a little weight is the second author.

The rest of the third, fourth, fifth, and sixth are actually members of the atmosphere group.

After the paper was published, everyone from Johnson & Johnson, Roche, Pfizer, and Novartis started to pay attention.

In the past, some research and development equipment focused on tea, but now it is different, and they directly put Zhang Fan and Chasu Hospital in the pool of scholars they focus on.

After the paper was published, GlaxoSmithKline in Mishima learned that Zhang Fan was coming to Mishima. They didn't pay much attention at first.

Because they are not very prominent in the research and development of drugs for the liver.

But they can directly represent the highest level of pharmaceuticals in terms of respiration, gastrointestinal tract, metabolism and anti-tumor.

So, when you see the new discovery of tea and meatball country. They're starting to take it seriously.

The head office directly contacted the Royal Hospital to inquire about Zhang Fan's itinerary.

Moreover, he had to prepare to make great efforts to publicize Zhang Fan.

Enterprises do not see blood but do not let go.

But the hospital in Mishima didn't see it that way.

"Do you think that Dr. Zhang Fan, who is called tea, is suspected of being fake? It's unbelievable that a liver and gallbladder expert can publish a world-class paper on colon."

"That's right! You can become the corresponding author, and the first author is a famous professor of colon in Wanzi Country!"

In the Royal Hospital, the director of the Hepatobiliary Department and the professor looked at the newly published paper together.

"Expand the number of participants in the speech. Let gastrointestinal experts also participate." The director of the Royal Hospital said directly.

"However, if Zhang Fan really cheats, will it affect our reputation!"

"No, no, no, if he is faked and found out by our hospital, it will give us more honor."

"Okay! Do you need to invite people from other countries?"

"Does our Big Three Island Empire need experts from other countries?"

Professor Royal said proudly.