Chapter 451 Embarrassment of Artemisinin

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Artemisinin is undoubtedly the pride of the Chinese people. Tu Youyou also won the Lasker Award and the Nobel Prize for this, which proves that the Chinese can also make some achievements in the field of medicine. However, in terms of application, artemisinin The situation was very embarrassing. ┏Ⅹ④③⑨⑨┛

China's development time is too short. At the beginning, I didn't know much about international business rules. Coupled with the high threshold built by international pharmaceutical giants, it was very difficult for domestic artemisinin drugs to enter the international market. In 1994, Nova took the opportunity to purchase the international sales rights of artemisinin compound drugs from the Chinese Academy of Medical Sciences, the original patent holder of artemisinin, at a low price. After five years of development, it became the first company in the world to launch fixed-dose artemisinin Pharmaceutical companies that compound or combine drugs.

Soon after, the World Health Organization recommended the use of compound artemisinin as the first antimalarial drug. Unfortunately, none of the Chinese pharmaceutical companies complied with GMP (World Health Organization Good Manufacturing Practice), so Novartis became the only qualified supplier at that time, and obtained a patent on compound artemisinin derivatives.

Since then, France Sanofi has also obtained some relevant patents and launched its own artemisinin drug, which led to the monopoly of the international artemisinin market by Nova, Sanofi and Indian generic drugs, and foreign pharmaceutical giants occupied the international market. The artemisinin drug market accounts for more than 90% of the market share, while Chinese artemisinin drugs only occupy less than 10% of the market.

This does not match China's status as the country where artemisinin was invented and the absolute main producer of raw materials. China has become a raw material producer of artemisinin and can only earn meager profits under the pressure of international pharmaceutical giants.

Moreover, because Nova and Sanofi have monopolized the artemisinin market, they not only have the pricing power of related drugs, but also continue to squeeze the purchase price of artemisinin raw materials, resulting in a continuous decline in the price of artemisinin raw materials. Most of the profits of the vegetarian industry are taken by Nova and Sanofi, and only a little leftovers are left for the domestic distribution.

"The entry standards of the pharmaceutical industry can be said to be set by those multinational pharmaceutical giants. It must be difficult for us to enter; in fact, no matter which industry is in a similar situation, the digital industry is also the same. Mobile phones, computers, playback terminals, etc., the rules and standards They are all monopolized by developed countries, and it is very difficult for our enterprises to enter." Shen Long said, "However, if you don't do some things, you will never have a chance. Only by doing it can you have hope."

Isn't that the case in the home appliance and mobile phone industries? After that, Chinese companies have gradually caught up with or even surpassed those in Europe, America, Japan, and South Korea. They have a certain say in the standard setting meeting, and they will launch advanced mobile phones ahead of foreign companies in the future. The road of the pharmaceutical industry is indeed more difficult than these industries. However, we occupy the largest market in the world and have unique patents in the world. It is not that there is no chance at all.

"Yeah, I hope this will be a good start." Director Qiao sighed, "What are you going to do next?"

"Let's write first,

Let people in the global industry know that we have made achievements that they failed to achieve, and then use Ron and them to stir up public opinion in the United States and expand their influence through public relations companies, prompting the FDA to accept our review request and carry out clinical trials. " Shen Long said.

"I don't know much about the situation in the United States, but it sounds like you are very careful and professional. If you need any help, just ask." Director Qiao was quite relieved, "It stands to reason that your achievement is fully qualified for the The Nobel Prize, but it is hard to say whether it will be won, because the western scientific community has always been prejudiced against traditional Chinese medicine."

It would be great if he could win the prize in a short period of time. With the influence of the Nobel Prize, there is no doubt that the speed of FDA review can be accelerated. I won the award only in 2015, even if I can win the award, I guess it will take a long time to wait.

It took Shen Long a few days to write the paper and submit it to the "New England Journal of Medicine". The paper immediately shocked the magazine, and they quickly distributed it to the authorities in related fields for review, and then published it as quickly as possible.

The publication of the paper caused an uproar in the global medical community. Originally, only Chinese medical practitioners knew that Shen Long’s new drug could treat leukemia, but now, almost the whole world knows it.

Many authoritative figures in this field rushed to Shanghai to learn about the latest developments in Shenlong's medical center and pharmaceutical factory. When they saw the medical records of each patient's improvement, they were all stunned. Human beings have conquered another terminal disease. They didn't think that this disease would be conquered, but they didn't expect that it would be a Chinese doctor who made this achievement, and the way of traditional Chinese medicine was adopted.

"It's unbelievable that the conditions of these patients are really under control, and they are still getting better." A senior professor from Hopkins University looked at the data just detected and said with emotion, "Cheng, you have made a great achievement." achievement."

"This is not the result of my own efforts, but the brilliance of traditional Chinese medicine." Shen Long did not monopolize the credit, "and Professor Ma Lin, Director Qiao, Mr. Weng and many other colleagues have also provided me with a lot of help. .”

"Cheng, such miraculous drugs should be available to patients all over the world. Are you ready to apply for FDA approval?" The professor at Harvard Medical School said excitedly. It is customary for pharmaceutical giants to bribe academia. things, but it does not mean that every medical authority is under their control, "If you have this intention, I am willing to help you."

"Now the production scale of the main raw materials is limited, and even the domestic demand cannot be completely solved. I think it may be possible to wait." Shen Long did not appear too eager, "And, as far as I know, Chinese medicines want to It seems to be very difficult to get through FDA review."

"Cheng, science should not have borders. American patients also need this drug." The Harvard professor persuaded, "As for FDA review, I have rich experience in this regard."

Those who came to look for Shen Long were not only scholars, but also representatives of pharmaceutical companies, and it was not just Nova who came back. These companies either threatened or lured them, and they all wanted to get this kind of medicine from Shen Long. drug patents.

"It is impossible to use patents on a global scale, and it is impossible to use patents overseas except in China. You should change to more realistic conditions!" As I said before, Shen Long is not at all I don't want to repeat the mistakes of artemisinin.